Flash Chromatography System

Medium pressure model Flash Chromatography System which could perfectly match with spin-welded columns for higher separation efficiency.

Binary gradient with any combinations of two solvents, 3rd solvent modifier, able to run complex separation conditions. Optional ELSD to cover more types of samples.

  • Gradient types: isocratic, linear, step
  • Flowcell optical path length: 0.3 mm (default); 2.4 mm (optional)
  • Spectral display: single/dual/all-wavelengths
  • Sample loading method: manual load
  • Fraction collection method: all, waste, threshold, slope, time
  • Fraction collector: Standard: tubes (13 mm, 15 mm,18 mm, 25 mm); Optional: Frencth square bottle (250 mL, 500 mL) or large collection bottle; Customizable collection container
  • Control device: wireless operation through mobile devices
  • Certificate: CE, cTUVus (in process)

Parameters of Flash Chromatography (Preparative Type)

ModelPreparative Type
Flow Range1 - 200 mL/min
Maximum Pressure500 psi (33.5 bar)
Pumping SystemHighly accurate dual piston pumps
GradientsFour solvents binary with 3rd solvent as modifier
Flash Column4g-3000g Column
Sample Loading Capacity10 mg - 160 g
DetectorDAD variable UV (200 - 400 nm) or DAD vairable UV (200 - 400 nm) + Vis (400 - 800 nm) or ELSD
Column Sizes4 g - 330 g, up to 3 kg with adapters

Smart purification system makes the purification easier

The smart flash chromatography system SepaBean® machine launched by Santai Technologies has the built-in feature of separation method recommendation. Even the beginners or non-professional chromatography operators could easily complete the purification task.

Smart purification with “Touch & GO” simplicity

SepaBean® machine is operated through mobile device, with iconized UI, it is simple enough for the beginner and nonprofessional to complete routine separation, but also sophisticated enough for the professional or guru to complete or optimized a complex separation.

Built-In Method Database — Knowledge Retained

Researchers around the world spent numerous resources to develop methods of separating and purifying compound mixtures, whether it’s synthesized mixtures, or extracts from natural products, these valuable methods are usually stored in a single location, isolated, disconnected, and become “information island” over the time. Unlike traditional flash instrument, SepaBean® machine employs database and distributed computing technology to retain and share these methods across a secured organizational network:

  • A built-in relational database to store separation methods, researchers can query existing or update new separation methods simply using compound name, structure or project code.
  • Network ready, multiple instruments within an organization can form a private channel, so that separation methods can be shared across the entire organization, authorized researchers can access and run these methods directly without having to re-develop the methods.
  • Discover and connect to peer instrument automatically, once multiple instruments are connected, data is automatically synced, researchers can access their methods in any connected inany connected instrument from any location.

Features of Flash Chromatography

  • Wireless Operation Through Mobile Devices

The flexible wireless control method is especially suitable for separation experiments that need to be protected from light or placed in an isolator.

  • Power Failure Recovery

The built-in power-off recovery function in the software minimizes the loss caused by accidental power failure.

  • Smart column Holder

Column holder with touchpad could achieve automatic fixing of the flash column.

  • Separation Method Recommendation

The software has a built-in separation method database that automatically recommends the most appropriate separation method based on the key information entered by the user, thereby improving work efficiency.

  • Fraction Collector

Tube racks with LCD display enable users to easily track the tubes containing collected fractions.

  • Local Network Data Sharing

Multiple instruments could form a local area network to facilitate internal data sharing and resource optimization in the laboratory.

  • RFID Technology

Automatic identification of current flash column information based on RFID technology, facilitating the use and maintenance of the columns.

  • 21-CFR Part 11 Compliance

The control software complies with FDA requirements for system safety (21-CFR Part 11), making the instrument more suitable for pharmaceutical R&D companies and laboratories.

Operation Interface & Analysis Testing

operation penal
  • Sample: Acetophenone and P-Methoxyacetophenone
  • Mobile Phase: 80% hexane and 20% ethyl acetate
  • Flow Rate: 250 mL/min
  • Sample Size: 40 mL
  • Wave Length: 254 nm

Chromatography Columns

Flash Chromatography Column
Flash Chromatography Column LOK
Flash Chromatography Column
Flash Chromatography Column

Other Flash Chromatography Types

Flow Range1 - 100 / 200 mL/min
Maximum Pressure100 psi (6.9 bar) / 200 psi (13.8 bar)
Pumping SystemHighly accurate, maintenance-free ceramic pump
GradientsTwo solvents, binary
DetectorFixed wavelength (254 nm, optional other wavelength) or DAD variable UV (200 - 400 nm) or DAD vairable UV (200 - 400 nm) + Vis (400 - 800 nm)
Loading Capacity10 mg - 33 g
Column Sizes4 g - 330 g, up to 3 kg with adapters
Flow Range1 - 200 mL/min
Maximum Pressure 200 psi (13.8 bar)
Pumping SystemHighly accurate, maintenance free ceramic pumps
GradientsFour solvents binary, high pressure mixing
DetectorDAD variable UV (200 - 400 nm) or DAD vairable UV (200 -400 nm) + Vis (400 - 800 nm) or ELSD
Loading Capacity10 mg - 33 g
Column Sizes4 g - 330 g, up to 3 kg with adapters

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